BAKER BROS ADVISORS LP
Q4 2024 Form 13-F
NEW YORK, NEW YORK
CIK 0001263508
· CRD 158149
· SEC-registered investment adviser
$9.4B Reported Value Total
BAKER BROTHERS INVESTMENTS reports 2 total accounts under management (AUM). There are 2 discretionary accounts valued at $18,024,640,582, and 0 non-discretionary accounts.
Source: Form ADV filed * Note that certain holdings are exempt from Form 13-F reporting, so the AUM totals may be greater than the Form 13-F total.
SEC Registered
Discretionary Manager
Private funds (Form ADV)
7 funds
· $28.2B gross asset value
Hedge Fund: $28.2B
Source: Form ADV filed 2026-03-27
Reported value
$9.4B
Quarter over quarter
-3.5%
Holdings
93
Top-10 concentration
76.5%
Key People
Form ADV owners & control persons
Felix James Baker
MANAGING MEMBER
Julian Charles Baker
MANAGING MEMBER
Scott Lawrence Lessing
PRESIDENT, CHIEF COMPLIANCE OFFICER
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Coverage begins with the second quarter of 2013. Earlier quarters are not shown while their accuracy is being verified.
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Q4 2024 13F record
Q4 2024 13F filing summary
| Period of report | December 31, 2024 |
|---|---|
| Filed | February 14, 2025 |
| Form | 13F-HR |
| Reported value | $9.4B |
| Positions | 93 |
| Change in reported value | -3.0% |
| New positions | 10 |
| Exited positions | 8 |
| Position turnover | 17.8% |
| Top-10 concentration | 76.5% |
13F filings by quarter
| Quarter | Positions | Value |
|---|---|---|
|
Q2 2026 13F
Filed Aug 14, 2026
|
83 | $20.0B |
|
Q1 2026 13F
Filed May 15, 2026
|
84 | $17.4B |
|
Q4 2025 13F
Filed Feb 17, 2026
|
85 | $17.1B |
|
Q3 2025 13F
Filed Nov 14, 2025
|
89 | $13.8B |
|
Q2 2025 13F
Filed Aug 14, 2025
|
88 | $10.3B |
|
Q1 2025 13F
Filed May 15, 2025
|
87 | $9.0B |
|
Q4 2024 13F
Filed Feb 14, 2025
|
93 | $9.4B |
|
Q3 2024 13F
Filed Nov 14, 2024
|
92 | $9.6B |
|
Q2 2024 13F
Filed Aug 14, 2024
|
93 | $7.8B |
|
Q1 2024 13F
Filed May 15, 2024
|
87 | $8.0B |
|
Q4 2023 13F
Filed Feb 14, 2024
|
82 | $8.8B |
|
Q3 2023 13F
Filed Nov 14, 2023
|
99 | $17.4B |
|
Q2 2023 13F
Filed Aug 14, 2023
|
106 | $17.3B |
|
Q1 2023 13F
Filed May 15, 2023
|
105 | $18.4B |
|
Q4 2022 13F
Filed Feb 14, 2023
|
111 | $16.7B |
|
Q3 2022 13F
Filed Nov 14, 2022
|
113 | $15.3B |
|
Q2 2022 13F
Filed Aug 15, 2022
|
114 | $17.6B |
|
Q1 2022 13F
Filed May 16, 2022
|
115 | $17.4B |
|
Q4 2021 13F
Filed Feb 14, 2022
|
116 | $20.6B |
|
Q3 2021 13F
Filed Nov 15, 2021
|
116 | $22.8B |
33 earlier quarters on file — choose one from the quarter menu above.
Top 20 holdings · Q4 2024
| # | Holding | Reported value | % of portfolio |
|---|---|---|---|
| 1 | INCY Incyte Corporation | $2.1B | 22.68% |
| 2 | ONC BeiGene, Ltd. | $1.8B | 18.81% |
| 3 | ACAD ACADIA Pharmaceuticals Inc. | $786.8M | 8.4% |
| 4 | MDGL Madrigal Pharmaceuticals, Inc. | $609.3M | 6.51% |
| 5 | SMMT Summit Therapeutics Inc. | $435.9M | 4.66% |
| 6 | RVMD Revolution Medicines, Inc. | $347.2M | 3.71% |
| 7 | INSM Insmed Incorporated | $345.7M | 3.69% |
| 8 | RYTM Rhythm Pharmaceuticals, Inc. | $340.6M | 3.64% |
| 9 | KYMR Kymera Therapeutics, Inc. | $241.2M | 2.58% |
| 10 | KOD Kodiak Sciences Inc. | $172.2M | 1.84% |
| 11 | EWTX Edgewise Therapeutics, Inc. | $164.4M | 1.76% |
| 12 | BCYC Bicycle Therapeutics plc | $152.4M | 1.63% |
| 13 | REPL Replimune Group, Inc. | $133.8M | 1.43% |
| 14 | ALKS Alkermes plc | $120.3M | 1.28% |
| 15 | INSM 0.75 06/01/28 Insmed Incorporated | $92.9M | 0.99% |
| 16 | TRDA Entrada Therapeutics, Inc. | $84.1M | 0.9% |
| 17 | ABCL AbCellera Biologics Inc. | $80.7M | 0.86% |
| 18 | DNLI Denali Therapeutics Inc. | $76.1M | 0.81% |
| 19 | NRIX Nurix Therapeutics, Inc. | $73.1M | 0.78% |
| 20 | ARGX argenx SE | $68.8M | 0.74% |
Values as reported on the Q4 2024 Form 13F. Every position is in the holdings table below.