RTW INVESTMENTS LP's Q3 2023 13F: 10 new positions, 5 exits
Form 13F-HR for the quarter ended Sep 30, 2023 · filed Nov 14, 2023 · 67 reported positions · accession 0001493152-23-040729
What changed this quarter
| Activity | Security | Weight before | Weight now | Change | Shares | Shares % |
|---|---|---|---|---|---|---|
| New | SAGE THERAPEUTICS INC (SAGE) | — | 2.2% | +2.2 pts | +5.15M sh | new |
| Increased | MIRATI THERAPEUTICS INC (MRTX) | 3.1% | 6.2% | +3.1 pts | +2.3M sh | +51% |
| Exited | HORIZON THERAPEUTICS PUB L (HZNP) | 2.0% | — | −2.0 pts | −1M sh | −100% |
| New | TAYSHA GENE THERAPIES INC (TSHA) | — | 1.1% | +1.1 pts | +16.89M sh | new |
| Exited | INTUITIVE SURGICAL INC (ISRG) | 1.1% | — | −1.1 pts | −170K sh | −100% |
| New | APOGEE THERAPEUTICS INC (APGE) | — | 1.0% | +1.0 pts | +2.14M sh | new |
| Increased | ACADIA PHARMACEUTICALS INC (ACAD) | 4.5% | 5.1% | +0.6 pts | +1.79M sh | +18% |
| Increased | BRUKER CORP (BRKR) | 4.2% | 4.4% | +0.3 pts | +422K sh | +14% |
| Reduced | ILLUMINA INC (ILMN) | 1.3% | 0.5% | −0.8 pts | −188K sh | −50% |
| New | ALKERMES PLC (ALKS) | — | 0.5% | +0.5 pts | +889K sh | new |
| Reduced | AXONICS INC (AXNX) | 0.9% | 0.5% | −0.3 pts | −442K sh | −50% |
| New | SHOCKWAVE MED INC (SWAV) | — | 0.5% | +0.5 pts | +124K sh | new |
| Increased | MERUS N V (MRUS) | 0.5% | 1.0% | +0.5 pts | +946K sh | +90% |
| Increased | INSMED INC (INSM) | 0.4% | 1.0% | +0.6 pts | +865K sh | +87% |
| Exited | MARAVAI LIFESCIENCES HLDGS I (MRVI) | 0.4% | — | −0.4 pts | −1.53M sh | −100% |
| New | ALLURION TECHNOLOGIES INC (ALUR) | — | 0.3% | +0.3 pts | +3.46M sh | new |
| Increased | AXSOME THERAPEUTICS INC (AXSM) | 5.9% | 6.6% | +0.8 pts | +205K sh | +5% |
| Increased | MADRIGAL PHARMACEUTICALS INC (MDGL) | 1.0% | 1.0% | 0.0 pts | +87,923 sh | +40% |
| Increased | ARGENX SE (ARGX) | 3.6% | 5.3% | +1.7 pts | +25,000 sh | +5% |
| Increased | GH RESEARCH PLC (GHRS) | 0.5% | 0.7% | +0.2 pts | +1.16M sh | +53% |
| Reduced | VIKING THERAPEUTICS INC (VKTX) | 0.3% | 0.1% | −0.2 pts | −741K sh | −74% |
| Exited | BLACK DIAMOND THERAPEUTICS I (BDTX) | 0.2% | — | −0.2 pts | −1.7M sh | −100% |
| New | STRYKER CORPORATION (SYK) | — | 0.2% | +0.2 pts | +28,000 sh | new |
| Reduced | OLINK HLDG AB (OLK) | 0.2% | 0.1% | −0.2 pts | −491K sh | −75% |
| Increased | TARSUS PHARMACEUTICALS INC (TARS) | 0.9% | 1.1% | +0.2 pts | +333K sh | +13% |
| Reduced | PMV PHARMACEUTICALS INC (PMVP) | 0.4% | 0.3% | −0.1 pts | −654K sh | −22% |
| New | SAGIMET BIOSCIENCES INC (SGMT) | — | 0.1% | +0.1 pts | +400K sh | new |
| Increased | IMMUNOCORE HLDGS PLC (IMCR) | 6.9% | 6.7% | −0.2 pts | +66,754 sh | +1% |
| Increased | AVADEL PHARMACEUTICALS PLC (AVDL) | 2.1% | 1.6% | −0.6 pts | +326K sh | +5% |
| Increased | 10X GENOMICS INC (TXG) | 1.6% | 1.3% | −0.2 pts | +57,000 sh | +4% |
| Increased | DESIGN THERAPEUTICS INC (DSGN) | 0.2% | 0.1% | −0.1 pts | +950K sh | +61% |
| Exited | MERSANA THERAPEUTICS INC (MRSN) | 0.0% | — | 0.0 pts | −615K sh | −100% |
| Increased | NATERA INC (NTRA) | 2.4% | 2.5% | +0.1 pts | +40,000 sh | +2% |
| Reduced | FULCRUM THERAPEUTICS INC (FULC) | 0.4% | 0.5% | +0.2 pts | −245K sh | −4% |
| New | RAYZEBIO INC (RYZB) | — | 0.0% | 0.0 pts | +46,300 sh | new |
| New | SIENTRA INC (SIENQ) | — | 0.0% | 0.0 pts | +304K sh | new |
| Increased | IMMUNIC INC (IMUX) | 0.2% | 0.1% | −0.1 pts | +40,796 sh | +1% |
Reported by the fund in its Form 13F filed with the SEC; holdings are as of the quarter-end report date and may have changed since. For informational purposes only — not investment advice or a recommendation to buy or sell any security. FilingExplorer is not affiliated with or endorsed by this fund. How this brief is compiled
Top 10 positions — 55.8% of the equity book
Changes in the top 10 this quarter: MRTX entered · ARGX entered · PTCT left · MASI left
| # | Security | Weight before | Weight now | |
|---|---|---|---|---|
| 1 | ROCKET PHARMACEUTICALS INC (RCKT) | 6.7% | 7.6% | |
| 2 | IMMUNOCORE HLDGS PLC (IMCR) | 6.9% | 6.7% | |
| 3 | AXSOME THERAPEUTICS INC (AXSM) | 5.9% | 6.6% | |
| 4 | ALNYLAM PHARMACEUTICALS INC (ALNY) | 6.1% | 6.3% | |
| 5 | MIRATI THERAPEUTICS INC (MRTX) | 3.1% | 6.2% | Entered the top 10 |
| 6 | ARGENX SE (ARGX) | 3.6% | 5.3% | Entered the top 10 |
| 7 | ACADIA PHARMACEUTICALS INC (ACAD) | 4.5% | 5.1% | |
| 8 | BRUKER CORP (BRKR) | 4.2% | 4.4% | |
| 9 | ULTRAGENYX PHARMACEUTICAL IN (RARE) | 4.7% | 4.1% | |
| 10 | PENUMBRA INC (PEN) | 4.4% | 3.4% | |
| — | PTC THERAPEUTICS INC (PTCT) | 5.6% | 3.4% | Left the top 10 |
| — | MASIMO CORP (MASI) | 4.7% | 2.8% | Left the top 10 |
Weights are each position's reported value as a share of the fund's reported equity positions (options and principal-amount holdings excluded).