RTW INVESTMENTS LP's Q1 2022 13F: 2 new positions, 20 exits
Form 13F-HR for the quarter ended Mar 31, 2022 · filed May 16, 2022 · 106 reported positions · accession 0001493152-22-013567
What changed this quarter
| Activity | Security | Weight before | Weight now | Change | Shares | Shares % |
|---|---|---|---|---|---|---|
| Exited | SPDR S&P 500 ETF TR (SPY) | 6.2% | — | −6.2 pts | −890K sh | −100% |
| Reduced | APELLIS PHARMACEUTICALS INC (APLS) | 1.4% | 0.1% | −1.3 pts | −1.94M sh | −97% |
| Exited | IVERIC BIO INC (ISEE) | 1.6% | — | −1.6 pts | −6.72M sh | −100% |
| Reduced | ITEOS THERAPEUTICS INC (ITOS) | 1.6% | 0.3% | −1.3 pts | −1.86M sh | −79% |
| Increased | PROTAGONIST THERAPEUTICS INC (PTGX) | 1.3% | 2.3% | +1.1 pts | +2.19M sh | +84% |
| Increased | C4 THERAPEUTICS INC (CCCC) | 1.2% | 2.3% | +1.1 pts | +2.04M sh | +82% |
| Reduced | ALNYLAM PHARMACEUTICALS INC (ALNY) | 4.9% | 5.7% | +0.8 pts | −293K sh | −15% |
| Exited | IDEAYA BIOSCIENCES INC (IDYA) | 0.9% | — | −0.9 pts | −2.52M sh | −100% |
| Increased | MASIMO CORP (MASI) | 3.6% | 3.4% | −0.2 pts | +278K sh | +33% |
| Exited | SAREPTA THERAPEUTICS INC (SRPT) | 0.8% | — | −0.8 pts | −582K sh | −100% |
| Reduced | THERMO FISHER SCIENTIFIC INC (TMO) | 4.2% | 4.6% | +0.3 pts | −62,500 sh | −14% |
| Exited | BELLUS HEALTH INC NEW (BLU) | 0.7% | — | −0.7 pts | −5.97M sh | −100% |
| Reduced | CELLDEX THERAPEUTICS INC NEW (CLDX) | 2.2% | 2.2% | 0.0 pts | −837K sh | −21% |
| New | CINCOR PHARMA INC (CINC) | — | 0.5% | +0.5 pts | +1.39M sh | new |
| New | 2SEVENTY BIO INC (TSVT) | — | 0.4% | +0.4 pts | +1.23M sh | new |
| Reduced | VERICEL CORP (VCEL) | 2.6% | 3.2% | +0.6 pts | −500K sh | −11% |
| Reduced | PROMETHEUS BIOSCIENCES INC (RXDX) | 1.9% | 2.2% | +0.3 pts | −506K sh | −16% |
| Reduced | JOHNSON & JOHNSON (JNJ) | 0.3% | 0.1% | −0.2 pts | −107K sh | −86% |
| Increased | PMV PHARMACEUTICALS INC (PMVP) | 1.0% | 1.7% | +0.7 pts | +891K sh | +30% |
| Increased | IMMUNOCORE HLDGS PLC (IMCR) | 0.6% | 1.2% | +0.5 pts | +614K sh | +49% |
| Reduced | TANDEM DIABETES CARE INC (TNDM) | 2.6% | 2.4% | −0.1 pts | −156K sh | −13% |
| Increased | BICYCLE THERAPEUTICS PLC (BCYC) | 0.8% | 1.2% | +0.4 pts | +407K sh | +47% |
| Increased | QUANTERIX CORP (QTRX) | 0.4% | 0.8% | +0.3 pts | +562K sh | +82% |
| Exited | ARROWHEAD PHARMACEUTICALS IN (ARWR) | 0.3% | — | −0.3 pts | −347K sh | −100% |
| Exited | CEREVEL THERAPEUTICS HLDNG I (CERE) | 0.3% | — | −0.3 pts | −667K sh | −100% |
| Reduced | AXONICS INC (AXNX) | 1.6% | 2.3% | +0.7 pts | −200K sh | −10% |
| Increased | JOUNCE THERAPEUTICS INC (JNCE) | 0.3% | 0.7% | +0.3 pts | +1.82M sh | +63% |
| Increased | IMMUNIC INC (IMUX) | 0.2% | 0.6% | +0.4 pts | +990K sh | +58% |
| Increased | PENUMBRA INC (PEN) | 2.6% | 3.1% | +0.5 pts | +45,000 sh | +7% |
| Reduced | ADVERUM BIOTECHNOLOGIES INC (ADVM) | 0.2% | 0.0% | −0.2 pts | −7.33M sh | −97% |
| Increased | RELMADA THERAPEUTICS INC (RLMD) | 0.7% | 1.4% | +0.7 pts | +354K sh | +16% |
| Reduced | PULMONX CORP (LUNG) | 0.5% | 0.4% | −0.1 pts | −366K sh | −31% |
| Increased | CUTERA INC (CUTRQ) | 0.8% | 2.2% | +1.3 pts | +129K sh | +9% |
| Reduced | GUARDANT HEALTH INC (GH) | 1.2% | 0.9% | −0.2 pts | −123K sh | −15% |
| Exited | NEOGENOMICS INC (NEO) | 0.2% | — | −0.2 pts | −311K sh | −100% |
| Exited | CLEARSIDE BIOMEDICAL INC (CLSD) | 0.2% | — | −0.2 pts | −3.81M sh | −100% |
| Exited | ORASURE TECHNOLOGIES INC (OSUR) | 0.1% | — | −0.1 pts | −1.15M sh | −100% |
| Reduced | NANOSTRING TECHNOLOGIES INC (NSTG) | 0.4% | 0.3% | −0.1 pts | −200K sh | −33% |
| Exited | ARBUTUS BIOPHARMA CORP (ABUS) | 0.1% | — | −0.1 pts | −2.5M sh | −100% |
| Increased | ILLUMINA INC (ILMN) | 2.7% | 3.7% | +1.0 pts | +18,976 sh | +4% |
| Increased | ARGENX SE (ARGX) | 1.6% | 2.2% | +0.6 pts | +19,531 sh | +6% |
| Reduced | FULCRUM THERAPEUTICS INC (FULC) | 1.0% | 1.8% | +0.8 pts | −256K sh | −7% |
| Reduced | AGENUS INC (AGEN) | 0.3% | 0.2% | −0.1 pts | −2.29M sh | −39% |
| Exited | VINCERX PHARMA INC (VINC) | 0.1% | — | −0.1 pts | −741K sh | −100% |
| Reduced | CASTLE BIOSCIENCES INC (CSTL) | 0.4% | 0.5% | +0.1 pts | −102K sh | −17% |
| Reduced | TELA BIO INC (TELA) | 0.3% | 0.2% | 0.0 pts | −382K sh | −27% |
| Exited | MERUS N V (MRUS) | 0.1% | — | −0.1 pts | −196K sh | −100% |
| Exited | BIOMEA FUSION INC (BMEA) | 0.1% | — | −0.1 pts | −594K sh | −100% |
| Reduced | PTC THERAPEUTICS INC (PTCT) | 3.1% | 4.0% | +1.0 pts | −72,738 sh | −1% |
| Increased | NATERA INC (NTRA) | 2.5% | 1.6% | −0.9 pts | +55,049 sh | +3% |
The 50 largest of 72 changes, by size of the trade. Full holdings for this quarter.
Reported by the fund in its Form 13F filed with the SEC; holdings are as of the quarter-end report date and may have changed since. For informational purposes only — not investment advice or a recommendation to buy or sell any security. FilingExplorer is not affiliated with or endorsed by this fund. How this brief is compiled
Top 10 positions — 38.7% of the equity book
Changes in the top 10 this quarter: ESTA entered · SPY left
| # | Security | Weight before | Weight now | |
|---|---|---|---|---|
| 1 | ALNYLAM PHARMACEUTICALS INC (ALNY) | 4.9% | 5.7% | |
| 2 | ROCKET PHARMACEUTICALS INC (RCKT) | 5.0% | 5.2% | |
| 3 | THERMO FISHER SCIENTIFIC INC (TMO) | 4.2% | 4.6% | |
| 4 | PTC THERAPEUTICS INC (PTCT) | 3.1% | 4.0% | |
| 5 | ILLUMINA INC (ILMN) | 2.7% | 3.7% | |
| 6 | MASIMO CORP (MASI) | 3.6% | 3.4% | |
| 7 | ESTABLISHMENT LABS HLDGS INC (ESTA) | 2.3% | 3.2% | Entered the top 10 |
| 8 | VERICEL CORP (VCEL) | 2.6% | 3.2% | |
| 9 | PENUMBRA INC (PEN) | 2.6% | 3.1% | |
| 10 | MIRATI THERAPEUTICS INC (MRTX) | 3.3% | 2.7% | |
| — | SPDR S&P 500 ETF TR (SPY) | 6.2% | 0.0% | Left the top 10 |
Weights are each position's reported value as a share of the fund's reported equity positions (options and principal-amount holdings excluded).