RTW INVESTMENTS LP's Q4 2021 13F: 17 new positions, 13 exits
Form 13F-HR for the quarter ended Dec 31, 2021 · filed Feb 14, 2022 · 124 reported positions · accession 0001493152-22-004326
What changed this quarter
| Activity | Security | Weight before | Weight now | Change | Shares | Shares % |
|---|---|---|---|---|---|---|
| Exited | DICERNA PHARMACEUTICALS INC (DRNA) | 2.3% | — | −2.3 pts | −7.58M sh | −100% |
| New | ULTRAGENYX PHARMACEUTICAL IN (RARE) | — | 1.7% | +1.7 pts | +1.37M sh | new |
| New | APELLIS PHARMACEUTICALS INC (APLS) | — | 1.4% | +1.4 pts | +1.99M sh | new |
| Increased | PENUMBRA INC (PEN) | 1.5% | 2.6% | +1.1 pts | +236K sh | +61% |
| Increased | ARGENX SE (ARGX) | 0.6% | 1.6% | +1.0 pts | +177K sh | +126% |
| New | BICYCLE THERAPEUTICS PLC (BCYC) | — | 0.8% | +0.8 pts | +869K sh | new |
| New | ADICET BIO INC (ACET) | — | 0.8% | +0.8 pts | +3.02M sh | new |
| New | SAREPTA THERAPEUTICS INC (SRPT) | — | 0.8% | +0.8 pts | +582K sh | new |
| Increased | PMV PHARMACEUTICALS INC (PMVP) | 0.4% | 1.0% | +0.6 pts | +2.17M sh | +268% |
| Increased | ALNYLAM PHARMACEUTICALS INC (ALNY) | 4.8% | 4.9% | +0.1 pts | +293K sh | +17% |
| New | SCIENCE 37 HOLDINGS INC (SNCE) | — | 0.7% | +0.7 pts | +3.98M sh | new |
| New | VENTYX BIOSCIENCES INC (VTYX) | — | 0.5% | +0.5 pts | +1.55M sh | new |
| New | QUANTERIX CORP (QTRX) | — | 0.4% | +0.4 pts | +686K sh | new |
| Increased | PROTAGONIST THERAPEUTICS INC (PTGX) | 0.5% | 1.3% | +0.8 pts | +846K sh | +48% |
| Increased | CYTOKINETICS INC (CYTK) | 1.1% | 1.7% | +0.6 pts | +561K sh | +28% |
| New | PYXIS ONCOLOGY INC (PYXS) | — | 0.3% | +0.3 pts | +2.12M sh | new |
| New | ARROWHEAD PHARMACEUTICALS IN (ARWR) | — | 0.3% | +0.3 pts | +347K sh | new |
| Exited | INMODE LTD (INMD) | 0.3% | — | −0.3 pts | −125K sh | −100% |
| Increased | CYTOMX THERAPEUTICS INC (CTMX) | 0.1% | 0.4% | +0.3 pts | +4.63M sh | +330% |
| Reduced | IDEAYA BIOSCIENCES INC (IDYA) | 1.3% | 0.9% | −0.4 pts | −746K sh | −23% |
| Increased | RELMADA THERAPEUTICS INC (RLMD) | 0.6% | 0.7% | +0.1 pts | +648K sh | +42% |
| Increased | THERMO FISHER SCIENTIFIC INC (TMO) | 3.6% | 4.2% | +0.7 pts | +19,500 sh | +5% |
| Increased | JOUNCE THERAPEUTICS INC (JNCE) | 0.2% | 0.3% | +0.2 pts | +1.47M sh | +105% |
| Reduced | GUARDANT HEALTH INC (GH) | 1.7% | 1.2% | −0.6 pts | −112K sh | −12% |
| Reduced | AGENUS INC (AGEN) | 0.7% | 0.3% | −0.4 pts | −3.21M sh | −35% |
| Increased | MIRATI THERAPEUTICS INC (MRTX) | 4.0% | 3.3% | −0.6 pts | +68,965 sh | +5% |
| Exited | LIFESCI ACQUISITION II CORP (LSAQ) | 0.1% | — | −0.1 pts | −975K sh | −100% |
| Reduced | ARBUTUS BIOPHARMA CORP (ABUS) | 0.3% | 0.1% | −0.2 pts | −2.23M sh | −47% |
| Reduced | NANOSTRING TECHNOLOGIES INC (NSTG) | 0.6% | 0.4% | −0.2 pts | −200K sh | −25% |
| New | ROIVANT SCIENCES LTD (ROIV) | — | 0.1% | +0.1 pts | +803K sh | new |
| Increased | BELLUS HEALTH INC NEW (BLU) | 0.5% | 0.7% | +0.2 pts | +1M sh | +20% |
| Increased | SPDR S&P 500 ETF TR (SPY) | 5.7% | 6.2% | +0.5 pts | +16,484 sh | +2% |
| Reduced | JOHNSON & JOHNSON (JNJ) | 0.4% | 0.3% | −0.1 pts | −45,415 sh | −27% |
| Exited | HELIX ACQUISITION CORP (HLXA) | 0.1% | — | −0.1 pts | −750K sh | −100% |
| New | MERUS N V (MRUS) | — | 0.1% | +0.1 pts | +196K sh | new |
| Increased | CUTERA INC (CUTRQ) | 0.9% | 0.8% | 0.0 pts | +139K sh | +11% |
| Exited | SCHOLAR ROCK HLDG CORP (SRRK) | 0.1% | — | −0.1 pts | −162K sh | −100% |
| Reduced | OLINK HLDG AB (OLK) | 0.5% | 0.3% | −0.2 pts | −300K sh | −23% |
| Exited | BERKELEY LTS INC (CELL) | 0.1% | — | −0.1 pts | −258K sh | −100% |
| Increased | MASIMO CORP (MASI) | 3.4% | 3.6% | +0.2 pts | +17,431 sh | +2% |
| Increased | PROQR THRAPEUTICS N V (PRQR) | 0.8% | 0.8% | 0.0 pts | +585K sh | +9% |
| Reduced | TANGO THERAPEUTICS INC (TNGX) | 0.1% | 0.0% | −0.1 pts | −419K sh | −70% |
| Exited | ACUTUS MED INC (AFIB) | 0.1% | — | −0.1 pts | −492K sh | −100% |
| Exited | APTEVO THERAPEUTICS INC (APVO) | 0.1% | — | −0.1 pts | −281K sh | −100% |
| Increased | OYSTER PT PHARMA INC (OYST) | 0.3% | 0.5% | +0.2 pts | +197K sh | +11% |
| Increased | RENOVACOR INC (RCOR) | 0.3% | 0.3% | 0.0 pts | +460K sh | +21% |
| New | ISOPLEXIS CORP (ISO) | — | 0.0% | 0.0 pts | +365K sh | new |
| Increased | IMMUNIC INC (IMUX) | 0.2% | 0.2% | +0.1 pts | +345K sh | +25% |
| Exited | MONTES ARCHIMEDES ACQUISITIO (MAAC) | 0.0% | — | 0.0 pts | −400K sh | −100% |
| Increased | ILLUMINA INC (ILMN) | 3.0% | 2.7% | −0.2 pts | +7,608 sh | +2% |
The 50 largest of 71 changes, by size of the trade. Full holdings for this quarter.
Reported by the fund in its Form 13F filed with the SEC; holdings are as of the quarter-end report date and may have changed since. For informational purposes only — not investment advice or a recommendation to buy or sell any security. FilingExplorer is not affiliated with or endorsed by this fund. How this brief is compiled
Top 10 positions — 38.3% of the equity book
Changes in the top 10 this quarter: ILMN entered · PEN entered · CLDX left · NTRA left
| # | Security | Weight before | Weight now | |
|---|---|---|---|---|
| 1 | SPDR S&P 500 ETF TR (SPY) | 5.7% | 6.2% | |
| 2 | ROCKET PHARMACEUTICALS INC (RCKT) | 7.1% | 5.0% | |
| 3 | ALNYLAM PHARMACEUTICALS INC (ALNY) | 4.8% | 4.9% | |
| 4 | THERMO FISHER SCIENTIFIC INC (TMO) | 3.6% | 4.2% | |
| 5 | MASIMO CORP (MASI) | 3.4% | 3.6% | |
| 6 | MIRATI THERAPEUTICS INC (MRTX) | 4.0% | 3.3% | |
| 7 | PTC THERAPEUTICS INC (PTCT) | 3.0% | 3.1% | |
| 8 | ILLUMINA INC (ILMN) | 3.0% | 2.7% | Entered the top 10 |
| 9 | PENUMBRA INC (PEN) | 1.5% | 2.6% | Entered the top 10 |
| 10 | VERICEL CORP (VCEL) | 3.3% | 2.6% | |
| — | CELLDEX THERAPEUTICS INC NEW (CLDX) | 3.2% | 2.2% | Left the top 10 |
| — | NATERA INC (NTRA) | 3.1% | 2.5% | Left the top 10 |
Weights are each position's reported value as a share of the fund's reported equity positions (options and principal-amount holdings excluded).