RA CAPITAL MANAGEMENT L P
Q4 2021 Form 13-F
BOSTON, MASSACHUSETTS
CIK 0001346824
· CRD 160174
· SEC-registered investment adviser
$5.7B Reported Value Total
RA CAPITAL MANAGEMENT, LP reports 9 total accounts under management (AUM). There are 9 discretionary accounts valued at $12,407,552,287, and 0 non-discretionary accounts.
Source: Form ADV filed * Note that certain holdings are exempt from Form 13-F reporting, so the AUM totals may be greater than the Form 13-F total.
Private funds (Form ADV)
6 funds
· $16.3B gross asset value
Hedge Fund: $14.5B · Venture Capital Fund: $1.8B
Source: Form ADV filed 2026-03-31
Reported value
$5.7B
Quarter over quarter
-24.4%
Holdings
97
Top-10 concentration
45.5%
Key People
Form ADV owners & control persons
Richard H. (mi Only) Aldrich
PARTNER
Peter (nmn) Kolchinsky
PORTFOLIO MANAGER
Craig Alan Randall
GENERAL COUNSEL
Filing Navigation
Coverage begins with the second quarter of 2013. Earlier quarters are not shown while their accuracy is being verified.
13F Metrics
Loading 13F Metrics
Q4 2021 13F record
Q4 2021 13F filing summary
| Period of report | December 31, 2021 |
|---|---|
| Filed | February 14, 2022 |
| Form | 13F-HR |
| Reported value | $5.7B |
| Positions | 97 |
| Change in reported value | -21.4% |
| New positions | 11 |
| Exited positions | 9 |
| Position turnover | 18.9% |
| Top-10 concentration | 45.5% |
13F filings by quarter
| Quarter | Positions | Value |
|---|---|---|
|
Q2 2026 13F
Filed Aug 14, 2026
|
84 | $11.5B |
|
Q1 2026 13F
Filed May 15, 2026
|
85 | $9.4B |
|
Q4 2025 13F
Filed Feb 17, 2026
|
71 | $9.8B |
|
Q3 2025 13F
Filed Nov 14, 2025
|
67 | $8.1B |
|
Q2 2025 13F
Filed Aug 14, 2025
|
63 | $5.9B |
|
Q1 2025 13F
Filed May 15, 2025
|
85 | $6.0B |
|
Q4 2024 13F
Filed Feb 14, 2025
|
89 | $7.5B |
|
Q3 2024 13F
Filed Nov 14, 2024
|
81 | $8.7B |
|
Q2 2024 13F
Filed Aug 14, 2024
|
78 | $7.6B |
|
Q1 2024 13F
Filed May 15, 2024
|
76 | $7.9B |
|
Q4 2023 13F
Filed Feb 14, 2024
|
62 | $6.4B |
|
Q3 2023 13F
Filed Nov 14, 2023
|
66 | $5.1B |
|
Q2 2023 13F
Filed Aug 14, 2023
|
54 | $5.3B |
|
Q1 2023 13F
Filed May 15, 2023
|
59 | $4.4B |
|
Q4 2022 13F
Filed Feb 14, 2023
|
70 | $4.9B |
|
Q3 2022 13F
Filed Nov 14, 2022
|
81 | $4.7B |
|
Q2 2022 13F
Filed Aug 15, 2022
|
88 | $3.8B |
|
Q1 2022 13F
Filed May 16, 2022
|
96 | $4.6B |
|
Q4 2021 13F
Filed Feb 14, 2022
|
97 | $5.7B |
|
Q3 2021 13F
Filed Nov 15, 2021
|
95 | $7.2B |
33 earlier quarters on file — choose one from the quarter menu above.
Top 20 holdings · Q4 2021
| # | Holding | Reported value | % of portfolio |
|---|---|---|---|
| 1 | ASND ASCENDIS PHARMA A/S | $1.0B | 17.95% |
| 2 | NVAX NOVAVAX INC | $300.1M | 5.29% |
| 3 | ITOS ITEOS THERAPEUTICS INC | $205.7M | 3.63% |
| 4 | TVTX TRAVERE THERAPEUTICS INC | $174.3M | 3.07% |
| 5 | JANX JANUX THERAPEUTICS INC | $171.1M | 3.02% |
| 6 | CTKB CYTEK BIOSCIENCES INC | $156.8M | 2.76% |
| 7 | IMGN IMMUNOGEN INC | $150.2M | 2.65% |
| 8 | ELYM ELIEM THERAPEUTICS INC | $137.6M | 2.43% |
| 9 | ICVX ICOSAVAX INC | $132.2M | 2.33% |
| 10 | DICE DICE THERAPEUTICS INC | $131.8M | 2.32% |
| 11 | VOR VOR BIOPHARMA INC | $129.2M | 2.28% |
| 12 | FMTX FORMA THERAPEUTICS | $128.1M | 2.26% |
| 13 | TYRA TYRA BIOSCIENCES INC | $101.8M | 1.8% |
| 14 | PCVX VAXCYTE INC | $100.9M | 1.78% |
| 15 | MGNX MACROGENICS INC | $98.0M | 1.73% |
| 16 | AVTE AEROVATE THERAPEUTICS INC | $97.4M | 1.72% |
| 17 | NKTX NKARTA INC | $86.0M | 1.52% |
| 18 | DAWN DAY ONE BIOPHARMACEUTICALS | $83.7M | 1.48% |
| 19 | TIL INSTIL BIO INC | $83.3M | 1.47% |
| 20 | BLU BELLUS HEALTH INC NEW | $82.4M | 1.45% |
Values as reported on the Q4 2021 Form 13F. Every position is in the holdings table below.