BRAIDWELL LP's Q2 2025 13F: 6 new positions, 13 exits
Form 13F-HR for the quarter ended Jun 30, 2025 · filed Aug 14, 2025 · 45 reported positions · accession 0001420506-25-002183
What changed this quarter
| Activity | Security | Weight before | Weight now | Change | Shares | Shares % |
|---|---|---|---|---|---|---|
| New | CARIS LIFE SCIENCES INC (CAI) | — | 9.3% | +9.3 pts | +7.32M sh | new |
| Reduced | TRANSMEDICS GROUP INC (TMDX) | 3.0% | 1.6% | −1.4 pts | −600K sh | −70% |
| Increased | KRYSTAL BIOTECH INC (KRYS) | 3.8% | 4.8% | +1.0 pts | +327K sh | +82% |
| Exited | BLUEPRINT MEDICINES CORP (BPMC) | 2.0% | — | −2.0 pts | −440K sh | −100% |
| Reduced | IRHYTHM TECHNOLOGIES INC (IRTC) | 3.0% | 2.2% | −0.8 pts | −256K sh | −46% |
| Increased | EDGEWISE THERAPEUTICS INC (EWTX) | 2.8% | 3.3% | +0.4 pts | +2.75M sh | +112% |
| Exited | BICARA THERAPEUTICS INC (BCAX) | 1.5% | — | −1.5 pts | −2.16M sh | −100% |
| Increased | INSPIRE MED SYS INC (INSP) | 2.5% | 3.2% | +0.7 pts | +220K sh | +73% |
| Increased | XENON PHARMACEUTICALS INC (XENE) | 4.7% | 5.4% | +0.7 pts | +895K sh | +33% |
| Increased | NUVALENT INC (NUVL) | 3.1% | 4.3% | +1.2 pts | +335K sh | +40% |
| Reduced | GUARDANT HEALTH INC (GH) | 2.9% | 2.1% | −0.9 pts | −490K sh | −37% |
| Reduced | KINIKSA PHARMACEUTICALS INTL (KNSA) | 2.3% | 1.5% | −0.8 pts | −860K sh | −44% |
| New | SIONNA THERAPEUTICS INC (SION) | — | 0.9% | +0.9 pts | +1.08M sh | new |
| Increased | ARGENX SE (ARGX) | 5.0% | 5.1% | +0.2 pts | +33,642 sh | +21% |
| Exited | ASCENDIS PHARMA A/S (ASND) | 0.9% | — | −0.9 pts | −107K sh | −100% |
| Exited | SAREPTA THERAPEUTICS INC (SRPT) | 0.8% | — | −0.8 pts | −235K sh | −100% |
| Reduced | LEGEND BIOTECH CORP (LEGN) | 5.3% | 4.3% | −1.0 pts | −436K sh | −15% |
| New | UNITEDHEALTH GROUP INC (UNH) | — | 0.7% | +0.7 pts | +49,400 sh | new |
| New | GLOBUS MED INC (GMED) | — | 0.7% | +0.7 pts | +247K sh | new |
| Reduced | ADAPTIVE BIOTECHNOLOGIES COR (ADPT) | 1.9% | 2.2% | +0.3 pts | −941K sh | −20% |
| Exited | IRONWOOD PHARMACEUTICALS INC (IRWD) | 0.5% | — | −0.5 pts | −6.62M sh | −100% |
| Reduced | REPLIMUNE GROUP INC (REPL) | 0.7% | 0.2% | −0.6 pts | −1.04M sh | −71% |
| Increased | CASTLE BIOSCIENCES INC (CSTL) | 0.4% | 0.8% | +0.4 pts | +457K sh | +125% |
| Reduced | APELLIS PHARMACEUTICALS INC (APLS) | 1.9% | 0.9% | −1.0 pts | −531K sh | −32% |
| Reduced | DAY ONE BIOPHARMACEUTICALS I (DAWN) | 1.5% | 0.7% | −0.8 pts | −1.36M sh | −38% |
| Exited | CULLINAN THERAPEUTICS INC (CGEM) | 0.4% | — | −0.4 pts | −981K sh | −100% |
| Increased | REPLIGEN CORP (RGEN) | 0.5% | 0.9% | +0.3 pts | +62,900 sh | +77% |
| Exited | DIANTHUS THERAPEUTICS INC (DNTH) | 0.4% | — | −0.4 pts | −375K sh | −100% |
| Reduced | ALPHATEC HLDGS INC (ATEC) | 2.3% | 1.9% | −0.3 pts | −624K sh | −15% |
| Reduced | ALIGN TECHNOLOGY INC (ALGN) | 4.4% | 4.5% | +0.1 pts | −33,800 sh | −6% |
| Exited | METSERA INC (MTSR) | 0.2% | — | −0.2 pts | −175K sh | −100% |
| Increased | PENUMBRA INC (PEN) | 1.5% | 1.6% | +0.1 pts | +19,500 sh | +18% |
| New | CRESCENT BIOPHARMA INC. (CBIO) | — | 0.2% | +0.2 pts | +262K sh | new |
| Exited | AARDVARK THERAPEUTICS INC (AARD) | 0.2% | — | −0.2 pts | −500K sh | −100% |
| Reduced | NEUROCRINE BIOSCIENCES INC (NBIX) | 6.9% | 7.0% | +0.1 pts | −31,500 sh | −3% |
| Exited | AEROVATE THERAPEUTICS INC (AVTE) | 0.2% | — | −0.2 pts | −1.44M sh | −100% |
| Increased | MADRIGAL PHARMACEUTICALS INC (MDGL) | 0.8% | 0.9% | 0.0 pts | +12,091 sh | +25% |
| Reduced | DYNE THERAPEUTICS INC (DYN) | 2.0% | 1.5% | −0.5 pts | −348K sh | −10% |
| Increased | THERMO FISHER SCIENTIFIC INC (TMO) | 3.3% | 2.6% | −0.7 pts | +7,500 sh | +6% |
| Reduced | APOGEE THERAPEUTICS INC (APGE) | 3.0% | 3.1% | +0.1 pts | −61,850 sh | −4% |
| Reduced | HARROW INC (HROW) | 1.3% | 1.3% | −0.1 pts | −84,593 sh | −9% |
| Reduced | GLAUKOS CORP (GKOS) | 3.2% | 3.0% | −0.2 pts | −21,021 sh | −3% |
| Exited | BETA BIONICS INC (BBNX) | 0.1% | — | −0.1 pts | −140K sh | −100% |
| Exited | SKYE BIOSCIENCE INC (SKYE) | 0.1% | — | −0.1 pts | −826K sh | −100% |
| New | SURROZEN INC (SRZN) | — | 0.1% | +0.1 pts | +140K sh | new |
| Increased | INTUITIVE SURGICAL INC (ISRG) | 2.3% | 2.3% | +0.1 pts | +1,600 sh | +2% |
| Reduced | ORUKA THERAPEUTICS INC (ORKA) | 0.8% | 0.8% | 0.0 pts | −47,584 sh | −3% |
| Exited | TREVI THERAPEUTICS INC (TRVI) | 0.0% | — | 0.0 pts | −72,083 sh | −100% |
| Increased | VIKING THERAPEUTICS INC (VKTX) | 1.8% | 1.8% | 0.0 pts | +1,600 sh | 0% |
Reported by the fund in its Form 13F filed with the SEC; holdings are as of the quarter-end report date and may have changed since. For informational purposes only — not investment advice or a recommendation to buy or sell any security. FilingExplorer is not affiliated with or endorsed by this fund. How this brief is compiled
Top 10 positions — 52.1% of the equity book
Changes in the top 10 this quarter: CAI entered · NUVL entered · EWTX entered · TMO left · DHR left · GKOS left
| # | Security | Weight before | Weight now | |
|---|---|---|---|---|
| 1 | CARIS LIFE SCIENCES INC (CAI) | 0.0% | 9.3% | Entered the top 10 |
| 2 | NEUROCRINE BIOSCIENCES INC (NBIX) | 6.9% | 7.0% | |
| 3 | XENON PHARMACEUTICALS INC (XENE) | 4.7% | 5.4% | |
| 4 | ARGENX SE (ARGX) | 5.0% | 5.1% | |
| 5 | KRYSTAL BIOTECH INC (KRYS) | 3.8% | 4.8% | |
| 6 | ALIGN TECHNOLOGY INC (ALGN) | 4.4% | 4.5% | |
| 7 | LEGEND BIOTECH CORP (LEGN) | 5.3% | 4.3% | |
| 8 | NUVALENT INC (NUVL) | 3.1% | 4.3% | Entered the top 10 |
| 9 | CG ONCOLOGY INC (CGON) | 4.2% | 4.1% | |
| 10 | EDGEWISE THERAPEUTICS INC (EWTX) | 2.8% | 3.3% | Entered the top 10 |
| — | THERMO FISHER SCIENTIFIC INC (TMO) | 3.3% | 2.6% | Left the top 10 |
| — | DANAHER CORPORATION (DHR) | 3.3% | 2.9% | Left the top 10 |
| — | GLAUKOS CORP (GKOS) | 3.2% | 3.0% | Left the top 10 |
Weights are each position's reported value as a share of the fund's reported equity positions (options and principal-amount holdings excluded).